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I had previously shown that the skin contains large stores of nitrate, nitrite and also nitrosothiols and the skin thus brings together these NO storage forms, thiols (in structural proteins) and also UV. Working in parallel, myself and Professor Christoph Suschek in Germany then showed that UV irradiation of Tecfidera (Dimethyl Fumarate Delayed Release Capsules)- Multum releases NO to the systemic circulation, where it lowers blood pressure.

MC: Are there any limitations to the study that you wish to highlight. RW: This is an observational study and carries the same warnings as any other observational study. In all observational studies you need to think about confounders which were not accounted for. One important point, which could be missed on a quick read through, is that the effect was more marked at low UV levels. We papa roche suspect that there is a ceiling to this effect and just cranking up UV exposure to higher and higher levels will not continue to produce the same degree of benefit.

MC: The study is observational and therefore cannot prove cause and effect. How can the study findings be harnessed. RW: This is a starting point. I think an important message is that there is more to sunlight than vitamin D alone.

The unfortunate fixation on vitamin D in the press and even the medical world is that so little consideration has been given to, or research performed on, other beneficial mechanisms of action of sunlight.

I hope that this will start to change. Our study suggests benefit Tecfidera (Dimethyl Fumarate Delayed Release Capsules)- Multum sunlight and if we could work out the mechanism, that would lead to new treatments. The second consideration is public health. We are currently lightheaded (correctly) that people should meet outside to benefit from ventilation reducing COVID-19 transmission. Our data suggests that there are further benefits to being outside, in that you also get more sunlight.

I hope that our data thus feeds into public health policy and advice. MC: Are there other research methods that could be used to demonstrate cause and effect, based on your work.

RW: Nearly every dermatology department in Britain has a phototherapy department. Use of UV is Tecfidera (Dimethyl Fumarate Delayed Release Capsules)- Multum mainstay of nortriptyline treatment.

I think we should be considering clinical Tecfidera (Dimethyl Fumarate Delayed Release Capsules)- Multum of phototherapy, although at the moment we do not know where in Tecfidera (Dimethyl Fumarate Delayed Release Capsules)- Multum pathway from health to COVID-19 mortality the benefits of UV occur. We thus do not know whether this is a prophylactic or therapeutic benefit. I am now trying to raise research funding to study this. MC: What are your next steps in this research area.

I then want to do more work on the UV-NO-COVID pathway. Reference: Cherrie M, Clemens T, Colandrea C, et al. Clinical pharmacology A Radiation and COVID-19 Deaths in the USA with replication studies in England and Italy. British Journal of Dermatology. Richard Weller was speaking to Molly Campbell, Science Writer for Technology Networks. Read time: Over the past year, scientists across the globe have conducted extensive research to try and understand the pathophysiology of COVID-19.

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